Publications - Journal

Use of Antibiotics in Neonatal Sepsis at Neonatal Unit of A Tertiary Care Hospital

Volumn 35, Issue 1 - March 01, 2011

Objectives
To assess the results of blood culture in neonatal sepsis and the sensitivity of the organisms to commonly used antibiotics in our set up.

Study Design
Observational descriptive study.
 
Place and Duration of Study
At neonatal unit of Shaikh Zayed hospital, Lahore from March 2009 to March 2010.
 
Material and Methods
150 patients meeting the inclusion criteria were included in the study. The blood culture and sensitivity patterns to the commonly used antibiotics were observed.
 
Results
Out of 150 presumed sepsis cases 48(32%) patients had culture proven sepsis. The most common organism isolated was Escherichia coli followed by Klebsiella, Pseudomonas auregenosa, Staphylococcus aureus and Staphylococcus epidermidis. Most of the organisms were resistant to ampicillin, gentamycin and even to cefotaxime. The organisms were relatively more sensitive to vancomycin and highly sensitive to imipenem.
 
Conclusion
The organisms isolated were almost the same as were in the previous studies. The rate of resistance of majority of the organisms to commonly used antibiotics has increased. The antibiotic policy adopted within a neonatal unit must be fit for local needs and should be sufficiently flexible to allow modification if susceptibility pattern changes.
 
Key words
Neonatal sepsis, culture and sensitivity, drug resistance

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